Cumulative Effects of Digitalis

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Extracardiac and coronary vascular effects of digitalis.

The administration of digitalis glycosides causes a variety of extracardiac effects. In both normal human subjects and in other species, digitalis increases smooth muscle tone of resistance and capacitance vessels. The vasoconstriction is mediated, in part, by a direct action of these glycosides on smooth muscle and, in part, by an increase in alpha-adrenergic tone. Constriction of coronary and...

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Effects of digitalis upon body electrolytes.

DURING the past decade, the relationship between digitalis drugs and potassium has been extensively investigated. Attention has been given primarily to the effect of potassium upon the digitalized state. It has been shown that administration of potassium abolishes the cardiotoxic manifestations of digitalis.' The converse has also been established, namely, that depletion of body potassium store...

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Effects of digitalis on myocardial ionic exchange.

SUMMARY Prior to consideration of the effects of digitalis compounds on ionic exchange the basic mechanisms of active Na+ and K+ transport are discussed. It is generally accepted that digitalis is a specific inhibitor of the Na+-K+ activated ATPase located primarily in the sarcolemmal membrane. Present evidence supports the concept that positive inotropic effects of digitalis are not seen unles...

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Cumulative effects of distributed interferers

Systems which re-use mains or phone wiring for communications purposes are currently of interest. As well as their obvious benefits they have the potential to cause interference to radio systems. Interference to receivers in the immediate vicinity is fairly readily measured and legislated for. However, with the potential for mass-market deployment of such systems it is also important to conside...

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Digitalis.

Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified their use in his late 18th century monograph on the efficacy of the leaves of the common foxglove plant (Digitalis purpurea). Despite their widespread acceptance into medical practice in the ensuing 200 years, both the efficacy and the safety of this class of drugs continu...

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ژورنال

عنوان ژورنال: The Boston Medical and Surgical Journal

سال: 1853

ISSN: 0096-6762,1533-4406

DOI: 10.1056/nejm185310050491004